Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice
The aim of the present study was to elucidate the pathogenic tinsupe role of endogenous 5-HT in pancreatitis.Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations.While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depl